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  1. Saporta D, McDaniel AB. Safety and efficacy comparison of multiple-antigen subcutaneous immunotherapy with multiple-antigen sublingual immunotherapy. Ear Nose Throat J. 2007; 86(8):493–497.
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  9. Gidaro GB, Marcucci F, Sensi L, et al. The safety of sublingual-swallow immunotherapy: an analysis of published studies. Clin Exp Allergy. 2005 May;35(5):565– 571.
  10. Andre C, Vatrinet C, Galvain S, et al. Safety of sublingual-swallow immunotherapy in children and adults. Int Arch Allergy Immunol. 2000;121:220–234.
  11. Canonica GW, Passalacqua G. Non injection routes for immunotherapy. J Allergy Clin Immunol. 2003:437–448.
  12. Reid MJ, Lockey RF, Turkeltaub PC, Platts-Mills TA. Survey of fatalities from skin testing and immunotherapy 1985– 1989. J Allergy Clin Immunol. 1993 Jul;92(1 Pt 1):6–15.
  13. Bernstein DI, Wanner M, Borish L, Liss GM. Twelve-year survey of fatal reactions to allergen injections and skin testing: 1990–2001. J Allergy Clin Immunol. 2004 Jun;113(6):1129–1136.
  14. Cox LS, Linnemann DL, Nolte H et al. Sublingual immunotherapy: a comprehensive review. J Allergy Clin Immunol. 2006; 117:1021–1035
  15. Bagnasco M, Passalacqua G, Villa G, et al. Pharmacokinetics of an allergen and a monomeric allergoid for oromucosal immunotherapy is allergic volunteers. Clin Exper All 2001; 31:54-60
  16. Wilson DR, Torres Lima R and Durham SR. Sublingual immunotherapy for allergic rhinitis: systematic review and meta-analysis. Allergy 2005; 60:4-12.
  17. Dunsky EH, Goldstein MF, Dvarin DJ, Belecanech GA. Anaphylaxis to sublingual immunotherapy. Allergy. 2006; 61:1235
  18. Eifan AO, Keles S, Bahceciler NN, Barlan IB. Anaphylaxis to multiple pollen allergen sublingual immunotherapy. Allergy. 2007 May;62(5):567–8. Epub 2007 Feb 20.
  19. Blazowski L. Anaphylactic shock because of sublingual immunotherapy overdose during third year of maintenance dose. Allergy. 2008 Mar;63(3):374. Epub 2007 Dec 8.
  20. Cochard MM, Eigenmann PA. Sublingual immunotherapy is not always a safe alternative to subcutaneous immunotherapy. J Allergy Clin Immunol
  21.  de Groot H, Bijl A.  Anaphylactic reaction after the first dose of sublingual immunotherapy with grass pollen tablet. Allergy. 2009 Jun;64(6):963-4.
  22. Ciprandi G and Marseglia, G. L. Safety of sublingual immunotherapy. Journal of Biological Regulators and Homeostatic Agents, 2011; (25) 1: 1–6.
  23. Mannino DM, Homa DM, Akinbami LJ, et al. Surveillance for asthma – United States, 1980–1999. Morb Mortal Wkly Rep. 2002;51(SS-1):1–14
  24. US Centers for Disease Control. Asthma [Web document]: www.cdc.gov/nchs/fastats/asthma.htm
  25. Saporta, D. Sublingual Immunotherapy and Asthma. Townsend Letter, October 2010:44-48
  26. This information on AE’s was gathered after more than 5 years of following these complaints. The information was presented (as well as guidelines for their management) at the Pan American Allergy Society Annual Meeting in Plano, Texas, March 23, 2012
  27. Wilson DR, Torres Lima R, Durham SR. Sublingual immunotherapy for allergic rhinitis: systematic review and meta-analysis. Allergy. 2005;60:4–12.
  28. Calamita Z, Saconato H, Pelá AB, Atallah AN. Efficacy of sublingual immunotherapy in asthma: systematic review of randomized-clinical trials using the Cochrane Collaboration method. Allergy. 2006 Oct;61(10):1162– 1172.
  29. Penagos M, Passalacqua G, Compalati E, et al. Metaanalysis of the efficacy of sublingual immunotherapy in the treatment of allergic asthma in pediatric patients, 3 to 18 years of age. Chest. 2008 Mar;133(3):599–609. Epub 2007 Oct 20.
  30. Larenas-Linnemann D. Sublingual immunotherapy in children: complete and updated review supporting evidence of effect. Curr Opin Allergy Clin Immunol. 2009 Apr;9(2):168–176.
  31. Gidaro GB, Marcucci F, Sensi L, et al. The safety of sublingual-swallow immunotherapy: an analysis of published studies. Clin Exp Allergy. 2005 May;35(5):565– 571.
  32. M. S. Khinchi, L. K. Poulsen, F. Carat, C. André, A. B.Hansen, and H. J. Malling, “Clinical efficacy of sublingual and subcutaneous birch pollen allergen-specific immunotherapy: a randomized, placebo-controlled, double-blind, double dummy study,” Allergy, vol. 59, no. 1, pp. 45–53, 2004.
  33. M. Mauroa, M. Russelloa, C. Incorvaiab, G.-B. Gazzolaa, G. Di Carac, and F. Frati, “Comparison of efficacy, safety and immunologic effects of subcutaneous and sublingual immunotherapy in birch pollinosis: a randomized study,” European Annals of Allergy and Clinical Immunology, vol. 39,no. 4, pp. 119–122, 2007.
  34. J. Pokladnikova, I. Krcmova, and J. Vlcek, “Economic evaluation of sublingual vs. subcutaneous allergen immunotherapy, “Annals of Allergy, Asthma and Immunology, vol. 100, no. 5, pp.482–489, 2008.
  35. C. Antunez, C. Mayorga, J. L. Corzo, A. Jurado, and M. J. Torres, “Two year follow-up of immunological response in mite allergic children treated with sublingual immunotherapy. Comparison with subcutaneous administration,” Pediatric Allergy and Immunology, vol. 19, no. 3, pp. 210–218, 2008.
  36. A. O. Eifan, T. Akkoc, A. Yildiz et al., “Clinical efficacy and immunological mechanisms of sublingual and subcutaneous immunotherapy in asthmatic/rhinitis children sensitized to house dust mite: an open randomized controlled trial,” Clinical and Experimental Allergy, vol. 40, no. 6, pp. 922–932, 2010.
  37. Saporta, D. Efficacy of Sublingual Immunotherapy versus Subcutaneous Injection Immunotherapy in Allergic Patients Journal of Environmental and Public Health Volume 2012, Article ID 492405, doi:10.1155/2012/492405
  38. Saporta, D. Sublingual immunotherapy: A Novel, albeit not so new, immunotherapy treatment modality. Am J Rhin 22, 1-00,2008; doi:10.2500/ajr.2008.22.3131
  39. Saporta, D. Sublingual Immunotherapy: An Alternative to Allergy Shots. Townsend Letter April 2012:64-68
  40. Finegold I. Allergen Immunotherapy: Present and future. Allergy Asthma Proc 2007; 28:44-49
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  45. Moller C, Dreborg S, Ferdousi HA, et al. Pollen immunotherapy reduces the development of asthma in children with seasonal rhinoconjunctivitis (the PAT-Study). J Allergy Clin Immunol. 2002;109:251–256.
  46. National Surveillance of Asthma: United States, 2001–2010: http://www.cdc.gov/nchs/data/series/sr_03/sr03_035.pdf
  47. Greineder DK. Risk management in allergen immunotherapy. J Allergy Clin Immunol. 1996 Dec;98(6 Pt 3):S330-4.
  48. Akçakaya N, Hassanzadeh A, Camcioğlu Y, Cokuğraş H. Local and systemic reactions during immunotherapy with adsorbed extracts of house dust mite in children. Ann Allergy Asthma Immunol. 2000 Oct;85(4):317-21.
  49. Lockey RF, Nicoara-Kasti GL, Theodoropoulos DS, Bukantz SC. Systemic reactions and fatalities associated with allergen immunotherapy. Ann Allergy Asthma Immunol. 2001 Jul;87(1 Suppl 1):47-55.
  50. H. S. Nelson, “Allergen immunotherapy: where is it now?” Journal of Allergy and Clinical Immunology, vol. 119, no. 4, pp. 769–777, 2007.
  51. Saporta D. Changes in Peak Flow Value during Immunotherapy Administration. Journal of Environmental and Public Health Volume 2012, Article ID 212867, doi:10.1155/2012/212867

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